研究领域:围绕关键生物标志物,尤其是肿瘤相关蛋白,以其为靶标展开诊疗探针与治疗药物设计,用于活细胞状态下靶标分子的检测、追踪与功能调控。
教育及工作经历:
2014.01-2017.11 香港浸会大学 博士
2017.11-2019.09 帝国理工学院 访问学者
2020.01-2021.10 香港理工大学 研究助理教授
2021.12-至今 3377app 研究员
代表性论文:
1. X Lu, L Li, S Pan, Y Jian, Yn Chen, W Yang, G Song*, X Fang*, P Ma*, L Jiang*. Self-Accelerating Bimetallic Peroxide Nanozymes for Cascade-Amplified Pyroptosis-Immunotherapy, Advanced Science (2026), accepted. (IF=14.1)
2. L Li, X Lu, Q He, C Shu, E R H Walter*, L Wang*, N J Long*, L Jiang*. NADPH-Independent Fluorescent Probe for Live-Cell Imaging of Heme Oxygenase-1, ACS Sensors (2025), 10, 1, 499-506. (IF=9.1)
3. L Jiang#, H L Lung#*, T Huang#, R Lan#, S Zha, L S Chan, W Thor, T-H Tsoi, H Chau, C Boreström, S Cobb, S W Tsao, G-L Law*, W-T Wong, W C-S Tai, W Y Chau, Y Du, A K S Chiang, J M Middendorf, N-K Mak*, N J Long*, K-L Wong*. Reactivation of Epstein Barr virus by a dual-responsive fluorescent EBNA1-targeting agent with zinc-chelating function, PNAS (2019), 116, 26614. (IF=9.1)
4. T Clough#, L Jiang#, K-L Wong*, N J Long*. Ligand design strategies to increase stability of gadolinium-based MRI contrast agents, Nature Communications (2019), 10, 1420. (IF=15.7)
5. L Jiang, R Lan, T Huang, C-F Chan, H Li, S Lear, J Zong, W-Y Wong, M M-L Lee, B D Chan, W-L Chan, W-S Lo, N-K Mak*, M L Lung, H L Lung, S W Tsao, G S Taylor, Z-X Bian, W C S Tai, G-L Law*, W-T Wong*, S L Cobb*, K-L Wong*. EBNA1-targeted probe for the imaging and growth inhibition of tumours associated with the Epstein-Barr virus, Nature Biomedical Engineering (2017), 1, 0042. (IF=26.7)
其他论文列表:
1. Y Hong, W Yang, Y Liu, S Pan, Q He, D Zhang, Y Luo, D Yang*, L Jiang*. Hemin as a UCNP Quencher for Constructing a NIR-Excitable Nanoprobe for Peroxynitrite, Sensors and Actuators: B: Chemical (2026), accepted. (IF=7.7)
2. Y Zhao#, Z Zhu#, L Li#, B Shi, Z Li, Y Huang, L Jiang*, C Shu*. Photoinduced site-selective thiosulfinylation of alkynols for the synthesis of oxathiolene oxides, Chinese Chemical Letters (2025), 36, 110900. (IF=8.9)
3. L Li#, W Yang#, Y Hong, Q He, X Lu, H Wang, P Tao, C Shu*, M Chen*, G Bao*, L Jiang*. Identification of Nanoplastics by Probing the Viscous Nanoenvironment, Small Science (2025), 5, e202500430. (IF=8.3)
4. S Zha#*, S Pan#, Y Jian, Y Peng, L Jiang*. Ultrasensitive and rapid detection of hydrogen sulfide by an upconversion nanosensor NaYF4:Yb3+, Tm3+@NaYF4@Ag2O, Materials & Design (2024), 237, 112546. (IF=7.9)
5. X Chen, J Wang, Z Mo, L Han, K Cheng, C Xie, G Liu*, L Jiang*, K Wang*, J Pan*. Development of Ru-polypyridyl complexes for real-time monitoring of Aβ oligomers and inhibition of Aβ fibril formation, Biomaterials Science (2024), 12, 1449-1453. (IF=5.7)
6. Y Luo*, Q Liu, P He, L Li, Z Zhang, X Li, G Bao, K-L Wong*, P A Tanner*, L Jiang*. Responsive Regulation of Energy Transfer in Lanthanide-Doped Nanomaterials Dispersed in Chiral Nematic Structure, Advanced Science (2023), 2303235. (IF=14.1)
7. X Fang#, D Yang#*, X Wu#, K-H Lui, X Li, W-S Lo, C Li, Y Zhang, G Nie, L Jiang*, Y Gu*, B Zhang*, W-T Wong*. Theoretical Calculation-Guided Engineering of Fe-Mn based Dual-Center Single-Atom Catalysts for Synergistic Tumor Therapy, Chemical Engineering Journal (2023), 474, 145675. (IF=13.2)
8. L Jiang#, H-N Mak#, E RH Walter, W-T Wong*, K-L Wong*, N J Long*. A fluorescent probe for the discrimination of oxidation states of palladium, Chemical Science (2021), 12, 9977-9982. (IF=7.5)
9. H-F Chau, Y Wu, W-Y Fok, W Thor, W C-S Cho, P Ma, J Lin, N-K Mak, J-C G Bunzli*, L Jiang*, N J Long*, H L Lung*, K-L Wong*. Lanthanide-based peptide-directed visible/near-infrared imaging and inhibition of LMP1, JACS Au (2021), 1, 1034-1043. (IF=8.7)
10. L Jiang, C Xie, H L Lung, K W Lo*, G-L Law*, N-K Mak*, K-L Wong*. EBNA1-targeted inhibitors: Novel approaches for the treatment of Epstein-Barr virus-associated cancers, Theranostics (2018), 8, 5307-5319. (Back Cover, IF=13.3)
科研/人才项目:
1. 国家自然科学基金面上项目(2024.01-2027.12,主持)
2. 湖北省高层次人才项目
3. 湖北省自然科学基金青年项目(2023.07-2025.06,主持)
4. 武汉市自然科学基金探索计划(晨光计划)项目(2025.06-2027.06,主持)
5. 3377app高层次人才引进项目
6. 中央高校基本科研业务费“基础研究”交叉专项项目(2026.04-2026.12,主持)
7. 中央高校基本科研业务费“基础研究”交叉专项项目(2025.04-2025.12,主持,滚动资助)
8. 中央高校基本科研业务费“基础研究”交叉专项项目(2024.06-2024.12,主持)
专利授权:
1. 江丽君; 李亮; 一种用于检测和标记微塑料的近红外荧光探针、其制备方法和应用, 2024-12-04, 中国, 202411770723X
2. Ka Leung Wong; Nai Ki Mak; Lijun Jiang; Zinc-binder based EBNA1-specific compounds, 2021-06-29, 美国, US 11,046,731 B2
3. Ka Leung Wong; Nai Ki Mak; Lijun Jiang; Therapeutic inhibitor for EBV-associated tumor with tailor responsive optical imaging, 2018-11-27, 美国, US 10,137,115 B2
荣誉/奖励:
3377app2024-2025学年度优秀学位论文(指导教师)
第十届全国老员工生命科学竞赛(科学探究类)一等奖(唯一指导教师)
湖北省老员工生物实验技能竞赛(2025)一等奖(唯一指导教师)
湖北省老员工生物实验技能竞赛(2024)二等奖(唯一指导教师)
获2020年度教育部高等学校科学研究优秀成果奖(科学技术)二等奖
获2019年香港科学会青年科学家奖(生命科学领域)
入选湖北省高层次人才项目
入选2022年3377app学者名师计划“桂子青年学者”
学术兼职:
Asian Journal of Pharmaceutical Sciences (IF=11.9),青年编委
View (IF=8.5),青年编委
Advanced Agrochem(Elsevier新期刊),青年编委
Journal of Luminescence (IF=3.6),Special Issue: The Evolution of Near-Infrared (NIR) Light: from Fundamental Spectroscopy to Biomedical Applications,客座编辑

